Which type of Ncrna is associated with breast cancer?

Second, lncRNAs are related with organ-specific breast cancer metastasis. Increasing evidence has shown that lncRNAs not only affect breast cancer lung metastasis, but also brain metastasis. Studies have shown that lncRNAs linc-ROR36,148, ANCR29,55, HOTAIR34, etc. regulate breast cancer lung metastasis.

How do you detect lncRNA?

To detect lncRNAs, there are two most common methods: microarrays and RNA sequencing (RNA-seq) using next generation sequencers. The former is well-established method, which has a rather long history for the detection of protein-coding genes.

What is the function of lncRNA?

lncRNAs are a new class of epigenetic regulators that play important roles in epigenetic regulation. lncRNAs regulate epigenetic modification primarily in the nucleus, regulating gene transcription at the transcriptional level by modulating histone or DNA modification, primarily methylation and acetylation.

Are miRNA Lncrna?

miRNAs are a class of noncoding RNA species (~22 nts) that play a central role in posttranscriptional regulation of protein coding genes by mRNA cleavage, direct translational repression and/or mRNA destabilization. LncRNAs can act as miRNA sponges, reducing their regulatory effect on mRNAs.

What is a lncRNA gene?

Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity.

What is the difference between lncRNA and miRNA?

In contrast to miRNAs, some lncRNAs are remarkably similar to messenger RNAs (mRNAs). lncRNAs are transcribed by RNA polymerase II, capped, spliced and get polyadenylated like mRNAs, although they cannot act as templates for protein synthesis [25].

Are miRNA lncRNA?

Is Pinky (pnky) a neural-specific lncRNA?

While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify Pinky (Pnky) as a neural-specific lncRNA that regulates neurogenesis from NSCs in the embryonic and postnatal brain.

Is pnky a conserved lncRNA that interacts with a key RNA processing factor?

These data thus unveil Pnky as a conserved lncRNA that interacts with a key RNA processing factor and regulates neurogenesis from embryonic and postnatal NSC populations. Copyright © 2015 Elsevier Inc. All rights reserved.

What is the role of lncRNA in cancer?

LncRNAs have emerged as critical regulators of cellular processes. LncRNA signatures are altered in almost all types of cancers. Aberrant lncRNA levels can be important cancer specific diagnostic markers. Deregulated lncRNAs can be targeted for cancer therapy.

Does pnky knockdown have a role in treating brain ischemia?

Main Text. Because SVZ NSCs generate new neurons that migrate to damaged brain areas, possibly for the replacement of damaged neurons after stroke ( Kernie and Parent, 2010), Pnky knockdown may have therapeutic potential in treating brain ischemia by promoting neural progenitor proliferation and reducing cell death.