Can you give Macrobid during pregnancy?

The antibiotics — trimethoprim-sulfamethoxazole (Bactrim) and nitrofurantoin (Macrobid) — have been linked to a small risk for birth defects in pregnant women when given in the first trimester.

Can nitrofurantoin be given in pregnancy?

It’s usually safe to take nitrofurantoin during pregnancy and while breastfeeding. It’s very unlikely that nitrofurantoin is harmful during pregnancy. It goes straight into your pee, so very little of the medicine passes through to the unborn baby.

Is Macrobid safe in pregnancy 3rd trimester?

Nitrofurantoin is safe and effective; however, poor tissue penetration has limited its use in pyelonephritis. In the past, nitrofurantoin was completely avoided in the third trimester because of hemolytic effects on the newborn. Currently, restriction of this agent is limited to the last several weeks of pregnancy.

Does Macrobid cause miscarriage?

Can taking nitrofurantoin in pregnancy cause miscarriage? One large study found no link between use of nitrofurantoin in early pregnancy and miscarriage. Ideally, further studies are required to confirm this finding.

Why is nitrofurantoin contraindicated in pregnancy?

In some advisements, the use of nitrofurantoin is contraindicated near term (38 to 42 weeks’ gestation) and during labor and delivery because of the potential for the induction of hemolytic anemia in the neonate, which is caused by low levels of red blood cell glutathione.

Can nitrofurantoin cause birth defects?

Nitrofurantoin and sulfonamides may cause major birth defects and should be used with caution—if at all—in women of reproductive age.

What birth defects does Macrobid cause?

The authors analyzed 13,155 women who had pregnancies affected by at least one major birth defect and concluded that nitrofurantoin use led to an increased prevalence of several fetal birth defects including hypoplastic left heart syndrome, ophthalmic malformations, atrial septal defects, and cleft lip.

Can nitrofurantoin cause a miscarriage?

What are the risks of using macrobid during pregnancy?

Background: In 2011, the American College of Obstetricians and Gynecologists (ACOG) released a committee opinion warning against the use of nitrofurantoin (Macrobid) during the first trimester of pregnancy due to the perceived risk of an increased rate of congenital abnormalities with its use (Committee Opinion 2017). While the committee continued to recommend that nitrofurantoin be used as a first-line agent during the second and third trimesters, they stated that it should only be

Can you take macrobid while your pregnancy?

Macrobid ® ( nitrofurantoin monohydrate/macrocrystalline) is a prescription antibiotic used to treat bladder infections. This drug is usually considered safe for use during pregnancy, although the full risks are not currently known. What Is Pregnancy Category B?

Is macrobid safe in 1st trimester pregnancy?

The antibiotics — trimethoprim-sulfamethoxazole (Bactrim) and nitrofurantoin (Macrobid) — have been linked to a small risk for birth defects in pregnant women when given in the first trimester.

What are Pregnancy Category X antibiotics?

5α-reductase inhibitors