What causes calcium pyrophosphate crystals to form?

Because CPPD tends to run in families, genes may play a role. Other possible factors in its development include excess stores of iron; low blood magnesium levels; an overactive parathyroid; a severely underactive thyroid; or excess calcium in the blood.

How does colchicine work for pseudogout?

Colchicine is used in the treatment of several auto-inflammatory conditions, including gout and pseudogout, and has recently been shown to completely block crystal-induced maturation of IL-1β in vitro, indicating that the drug acts upstream of inflammasome activation [Martinon et al. 2006].

What is the pathophysiology of pseudogout?

This condition results from the abnormal formation of calcium pyrophosphate dihydrate (CPPD) crystals in the cartilage (cartilage is the “cushion” between the bones) or the joint fluid (synovial fluid). This can lead to a sudden attack of arthritis similar to gout.

Does prednisone help pseudogout?

Prednisone can be given orally to abort an attack of pseudogout. It can be given intravenously if the patient cannot take it by mouth. Intra-articular corticosteroids are the first choice of therapy due to their excellent safety profile.

What are crystals associated with pseudogout?

Pseudogout has been linked to the presence of calcium pyrophosphate dihydrate crystals within the affected joint. These crystals become more numerous as people age, appearing in nearly half the population older than age 85.

Which is better colchicine or prednisone?

Conclusion: Low dose prednisolone and colchicine were both effective in treating RAS. Given that the two therapies had similar efficacy, yet colchicine was associated with more side effects, , 5mg/d of prednisolone seems to be a better alternative in reducing the signs and symptoms of the disease.

Is heat or cold better for pseudogout?

Ice. Cold packs can help reduce the inflammation associated with flare-ups.

Is turmeric better than glucosamine?

Whereas glucosamine structurally supports connective tissue integrity within the joint, turmeric offers greater protection against joint-diminishing oxidative stress, inflammation, and enzymes.